2025/10/27 by Rolando Claure‐Del Granado, Ravindra L. Mehta, all ADQI 32 panel members +34 · 1 voice
Medicine · #Cardiovascular Issues in Pregnancy #Coagulation, Bradykinin, Polyphosphates, and Angioedema #Pregnancy and Medication Impact
paper · doi:10.1093/ndt/gfaf226
openalex publication_date 2025/10/27 · openalex created_date 2025/10/28 · openalex updated_date 2026/08/01
Despite advancements in obstetric care, pregnancy-associated acute kidney injury (PrAKI) continues to be a significant public health concern, contributing to substantial maternal and fetal morbidity and mortality. The most common causes of PrAKI include preeclampsia/eclampsia, haemorrhage and infection. Diagnosis is influenced by gestational age and individual risk factors. Alongside traditional investigations such as imaging and kidney biopsy, novel diagnostics and biomarkers may provide valuable insights for differential diagnosis. This review aims to offer an update on the diagnostic approaches and investigational tools for PrAKI, while also addressing current challenges in the diagnostic paradigm and presenting recommendations for clinical practice and future research.