2023/10/19 by Lingyan Yang, Lei Shi, Yihui Liu +6
Biochemistry, Genetics and Molecular Biology · Engineering · #Cancer Research and Treatments #Cancer, Hypoxia, and Metabolism #Nanoplatforms for cancer theranostics
paper · doi:10.2174/0109298673264765231006062032
openalex publication_date 2023/10/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02
High concentrations of reactive oxygen species (ROS) can disrupt cell structure and induce apoptosis and necrosis of tumor cells. Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are two cancer treatments mediated by reactive oxygen species. Oxygen molecules (O<sub>2</sub>) are one of the indispensable factors in PDT and hypoxic tumor sites limit its application. However, another ROS-mediated method, CDT, can generate •OH and O<sub>2</sub><i>in situ</i> by Fenton reaction or Fenton-like reaction. Synergistic PDT/CDT therapy is a strategy to overcome the limitations of tumor microenvironment therapy. In this review, PDT and CDT therapies are briefly introduced, with an emphasis on metal-basrd porphyrin nanoparticles constructed in different ways for PDT/CDT dual-mode therapy. By introducing the history and latest design schemes of the treatment model, it provides ideas for researchers engaged in ROS-mediated cancer therapies.