2024/09/16 by Imane Yamari, Oussama Abchır, Oussama Abchir +7
Chemistry · Medicine · #Carbohydrate Chemistry and Synthesis #Click Chemistry and Applications #Peptidase Inhibition and Analysis
paper · doi:10.2174/0109298673321782240829082610
openalex publication_date 2024/09/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
INTRODUCTION: Aspergillus fumigatus, a significant fungal pathogen, poses a threat to human health, especially in immunocompromised individuals. Addressing the need for novel antifungal strategies, this study employs virtual screening to identify potential inhibitors of Fructosamine oxidase, also known as Amadoriase II, a crucial enzyme in Aspergillus fumigatus (PDB ID: 3DJE). METHODS: Virtual screening of 81,197 triazole derivatives was subjected to computational analysis, aiming to pinpoint molecules with high binding affinity to the active site of Fructosamine oxidase. Subsequently, an in-depth ADMET analysis assessed the pharmacokinetic properties of lead compounds, ensuring their viability for further development. Molecular dynamics simulations were performed to evaluate the stability of top-ranked compounds over time. RESULTS: The results unveil a subset of triazole derivatives displaying promising interactions, suggesting their potential as inhibitors for further investigation. CONCLUSION: This approach contributes to the development of targeted antifungal agents, offering a rational starting point for experimental validation and drug development against Aspergillus fumigatus infections.