2020/10/09 by Shivani Pathak, Laurie Slovarp, Matthew S Clary +3
Health Professions · Medicine · Neuroscience · #Infant Health and Development #Neuroscience of respiration and sleep #Respiratory and Cough-Related Research
paper · doi:10.1093/chemse/bjaa069
openalex publication_date 2020/10/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
The larynx plays a key role in airway protection via the laryngeal chemoreflex (LCR). This involuntary reflex can be evoked when hazardous substances activate mucosal receptors, which send signals to be processed within the brainstem. Although the LCR is meant to be protective, the reflex can become hyperstimulated, even to benign stimuli, which can result in pathological disorders, such as chronic cough and inducible laryngeal obstruction. In this review, we will outline the mechanism of the LCR and its associated pathological disorders.