1947/01/01 by E. Chargaff, Erwin Chargaff · 1 citation
Biochemistry, Genetics and Molecular Biology · #Porphyrin Metabolism and Disorders #Protist diversity and phylogeny #Yeasts and Rust Fungi Studies
paper · doi:10.1101/sqb.1947.012.01.006
openalex publication_date 1947/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
The difficulties confronting the cytochemist in his attempt to study the composition of indigenous cellular constituents are multiplied in the case of microorganisms, owing to limitations of size and availability of material. It is, therefore, rather remarkable that interest in microbial nucleoproteins and nucleic acids extends to the very beginning of our knowledge of this subject. This early attention is undoubtedly due to the acuteness of two men, Miescher and Hoppe-Seyler, who in a flash of insight rarely equaled in the history of the biological sciences recognized the importance of this group of substances almost immediately after their discovery in animal and plant cells. Following the isolation by Miescher of nucleic acid from pus cells, Hoppe-Seyler repeated these experiments and at the same time reported the discovery of a similar compound in yeast (Hoppe-Seyler, 1871).