2022/03/22 by Daniel Villalba Lopez, Martin Kongsbak‐Wismann · 1 citation
Immunology and Microbiology · Medicine · #Dermatology and Skin Diseases #IL-33, ST2, and ILC Pathways #Psoriasis: Treatment and Pathogenesis
paper · doi:10.1111/apm.13221
openalex publication_date 2022/03/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. IL-22 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil-attracting chemokines. IL-22 plays an important role in wound healing and in the protection against skin infections. However, IL-22 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL-22 is discussed with a special focus on the role of IL-22 in the skin and in skin diseases.