2021/01/18 by Agrima Mian, Nirmal Andrapalliyal, Allison L. Weathers +2
Engineering · Medicine · #CAR-T cell therapy research #Polyomavirus and related diseases #Semiconductor materials and devices
paper · doi:10.1111/ejh.13583
openalex publication_date 2021/01/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Progressive multifocal leukoencephalopathy (PML) is a life-threatening infection of the central nervous system in immunocompromised patients, with an established predilection in non-Hodgkin's lymphoma and stem cell transplant recipients. In the era of chimeric antigen receptor T-cell therapy (CAR T-cell), the occurrence of new-onset neurological symptoms and encephalopathy in this patient population can be attributed to a variety of factors, including therapy-related neurotoxicity or disease progression. PML has not been implicated as a common cause of encephalopathy in CAR T-cell therapy recipients, and the identification of such rare infections is important to guide prognosis and treatment decisions. We hereby report the first case of late occurrence of PML, over one year after CAR T-cell therapy, for a patient with relapsed large B-cell lymphoma.