The Gut-Brain Axis in Alzheimer’s Disease: Exploring Microbial Influences and Therapeutic Strategies

2025/11/24 by Mohammed Ahmed Mustafa, Nasir Vadia, Pooja Varma +8
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Alzheimer's disease research and treatments #Barrier Structure and Function Studies #Gut microbiota and health

paper · doi:10.1007/s12035-025-05474-4

openalex publication_date 2025/11/24 · openalex created_date 2025/11/25 · openalex updated_date 2026/08/02

Citations

• Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial
• A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
• Molecular mechanisms of neurodegeneration in Alzheimer's disease
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
• The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease
• Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
• Microglia in Alzheimer’s disease
• Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
• The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review
• Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
• Gut microbiota in human metabolic health and disease
• The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies
• Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
• Transplantation of gut microbiota derived from Alzheimer’s disease mouse model impairs memory function and neurogenesis in C57BL/6 mice
• Fish intake, n-3 fatty acid body status, and risk of cognitive decline: a systematic review and a dose–response meta-analysis of observational and experimental studies
• Microglia: Immune and non-immune functions
• Gut microbiome and health: mechanistic insights
• Microbiota in health and diseases
• 2023 Alzheimer's disease facts and figures
• Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review