The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model

2020/04/07 by Mele N. Avilla, Kristen M. C. Malecki, Kristen Malecki +3
Medicine · Biochemistry, Genetics and Molecular Biology · #Adipose Tissue and Metabolism #Cancer, Hypoxia, and Metabolism #Retinoids in leukemia and cellular processes

paper · pdf · doi:10.1021/acs.chemrestox.9b00476

Abstract

-dioxins ("dioxins"), and many polyhalogenated biphenyls. To provide a platform for future research, we provide the historical underpinnings of our current state of knowledge about AHR signal transduction, identify a few areas of needed research, and then develop concepts such as adaptive metabolism, ligand structural diversity, and the importance of proligands in receptor activation. We finish with a discussion of the cognate physiological role of the AHR, our perspective on why this receptor is so highly conserved, and how we might think about its cognate ligands in the future.

Citations

• An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
• Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models.
• Distribution of mRNAs encoding the arylhydrocarbon receptor, arylhydrocarbon receptor nuclear translocator, and arylhydrocarbon receptor nuclear translocator-2 in the rat brain and brainstem

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