Small Randomized Trial Among Low–birth-weight Children Receiving Bacillus Calmette-Guérin Vaccination at First Health Center Contact

2011/12/21 by Sofie Biering‐Sørensen, Sofie Biering-Sørensen, Peter Aaby +7 · 7 citations
Immunology and Microbiology · Medicine · #Immune responses and vaccinations #Immunodeficiency and Autoimmune Disorders #Neonatal Respiratory Health Research

paper · doi:10.1097/inf.0b013e3182458289

openalex publication_date 2011/12/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guérin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.

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