AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function

2011/09/15 by D. Grahame Hardie · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Metabolism, Diabetes, and Cancer #Pancreatic function and diabetes

paper · pdf · doi:10.1101/gad.17420111

openalex publication_date 2011/09/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP. Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation. Both tumor cells and viruses establish mechanisms to down-regulate AMPK, allowing them to escape its restraining influences on growth.

Citations

• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
• Model Transformation Framework Supported by ZOOM.

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