The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

2018/07/21 by Steffen E. Storck, Anika M. S. Hartz, Anika M.S. Hartz +8 · 2 citations
Medicine · Nursing · #Alzheimer's disease research and treatments #Drug Transport and Resistance Mechanisms #Trace Elements in Health

paper · doi:10.1016/j.bbi.2018.07.017

openalex publication_date 2018/07/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

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• Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
• Multivalent modulation of endothelial LRP1 induces fast neurovascular amyloid-β clearance and cognitive function improvement in Alzheimer’s disease models