Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice

2022/11/01 by Dan Cheng, Zongshi Qin, Zong-Shi Qin +10
Neuroscience · #Neuroinflammation and Neurodegeneration Mechanisms #Stress Responses and Cortisol #Tryptophan and brain disorders

paper · doi:10.1016/j.bbi.2022.10.022

openalex publication_date 2022/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Citations

• Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies
• Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy
• Overview of General and Discriminating Markers of Differential Microglia Phenotypes
• Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis