2014/02/07 by Onur Varol, Deniz Yüret, Deniz Yuret +2
Biochemistry, Genetics and Molecular Biology · Chemistry · Physics and Astronomy · #Mass Spectrometry Techniques and Applications #Protein Structure and Dynamics #Spectroscopy and Quantum Chemical Studies
paper · doi:10.1002/prot.24531
openalex publication_date 2014/02/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Relevance of mode coupling to energy/information transfer during protein function, particularly in the context of allosteric interactions is widely accepted. However, existing evidence in favor of this hypothesis comes essentially from model systems. We here report a novel formal analysis of the near-native dynamics of myosin II, which allows us to explore the impact of the interaction between possibly non-Gaussian vibrational modes on fluctutational dynamics. We show that an information-theoretic measure based on mode coupling alone yields a ranking of residues with a statistically significant bias favoring the functionally critical locations identified by experiments on myosin II.