1986/01/01 by L. G. Schmitt, Lester Schmitt, J. E. Shaw +1
Medicine · Neuroscience · #Allergic Rhinitis and Sensitization #Olfactory and Sensory Function Studies #Vestibular and auditory disorders
paper · doi:10.1001/archotol.1986.03780010090017
openalex publication_date 1986/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Twelve healthy subjects received seven-day treatments on a randomized, double-blind, crossover basis, of a transdermal scopolamine system, oral meclizine, and placebo, separated by one-week intervals. Just prior to each treatment, and on days 1 and 7 of each treatment, subjects received two warm (44 degrees C) caloric irrigations of each external auditory canal. Following each irrigation, subjects rated their vertigo symptoms. Subjects reported on their side effects daily throughout each treatment period. Vertigo symptoms on day 1 of treatment were significantly less with transdermal scopolamine than oral meclizine or placebo and on day 7 were significantly less with both scopolamine and meclizine than the placebo. On day 1, meclizine did not reduce vertigo symptoms significantly when compared with the placebo. Drowsiness was greater with use of oral meclizine than transdermal scopolamine.