2005/01/31 by Edoardo G. Giannini, E. G. Giannini · 1 citation
Medicine · #Liver Disease Diagnosis and Treatment #Drug Transport and Resistance Mechanisms #Liver Disease and Transplantation
paper · pdf · doi:10.1503/cmaj.1040752
Isolated alterations of biochemical markers of liver damage in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.