2025/03/21 by Catharina J. Küng, Michael Lazarou, Thanh Ngoc Nguyen · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #CRISPR and Genetic Engineering #Calcium signaling and nucleotide metabolism
paper · doi:10.1016/j.ceb.2025.102493
Mitophagy is an important lysosomal degradative pathway that removes damaged or unwanted mitochondria to maintain cellular and organismal homeostasis. The mechanisms behind how mitophagy is initiated to form autophagosomes around mitochondria have gained a lot of interest since they can be potentially targeted by mitophagy-inducing therapeutics. Mitophagy initiation can be driven by various autophagy receptors or adaptors that respond to different cellular and mitochondrial stimuli, ranging from mitochondrial damage to metabolic rewiring. This review will cover recent advances in our understanding of how mitophagy is initiated, and by doing so reveal the mechanistic plasticity of how autophagosome formation can begin.