2009/09/01 by Menachem Ailenberg, Ori D. Rotstein · 1 citation
Biochemistry, Genetics and Molecular Biology · Computer Science · Mathematics · #Algorithms and Data Compression #Artificial intelligence #Biology #Coding (social sciences) #Coding region #Computational biology #Computer science #DNA #DNA and Biological Computing #DNA sequencing #Data compression #Gene #Genetics #Genomics and Phylogenetic Studies #Huffman coding #Information retrieval #Mathematics
paper · doi:10.2144/000113218
openalex publication_date 2009/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
An improved Huffman coding method for information storage in DNA is described. The method entails the utilization of modified unambiguous base assignment that enables efficient coding of characters. A plasmid-based library with efficient and reliable information retrieval and assembly with uniquely designed primers is described. We illustrate our approach by synthesis of DNA that encodes text, images, and music, which could easily be retrieved by DNA sequencing using the specific primers. The method is simple and lends itself to automated information retrieval.