1991/05/01 by Michael H. Huo, Nancy W. Troiano, Nancy Troiano +3
Medicine · Nursing · #Inflammatory mediators and NSAID effects #Spine and Intervertebral Disc Pathology #Vitamin K Research Studies
paper · doi:10.1002/jor.1100090310
openalex publication_date 1991/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Ibuprofen is a widely used cyclo-oxygenase inhibitor in clinical practice. It has been demonstrated by others to have an inhibitory effect on fracture repair in animals. In the present study, we were unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague-Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12-week time interval. Fracture histology and serum osteocalcin levels were no different in treated animals than control animals. Furthermore, histomorphometric parameters of bone remodeling, including bone volume and bone formation rate in the intact tail vertebrae of these animals with unilateral femur fractures, were no different between treated and control animals.