Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats.

2007/01/01 by Mark Good, M. A. Good, Patrick D. Barnes +5 · 4 citations
Neuroscience · #Memory and Neural Mechanisms #Neuroscience and Neuropharmacology Research #Stress Responses and Cortisol

paper · doi:10.1037/0735-7044.121.1.218

Abstract

Dual-process models of recognition memory in animals propose that recognition memory is supported by two independent processes that reflect the operation of distinct brain structures: a familiarity process that operates independently of the hippocampus and a context-dependent (episodic) memory process that is dependent on the hippocampus. A novel variant of an object recognition procedure was used to examine this proposal. Healthy rats showed a preference for exploring a novel object rather than a familiar object: a familiarity-dependent recognition effect. They also showed a preference for exploring a familiar object that was presented in a different spatiotemporal context rather than a familiar object that was presented either in a different spatial or temporal context: a context-dependent form of recognition that is sensitive to "what" object has been presented "where" and "when." Rats with excitotoxic hippocampal lesions showed the familiarity-dependent but not the context-dependent form of recognition. The results provide support for dual-process theories of recognition memory.

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