2023/09/25 by Erin F. Gillespie, Joanna C. Yang, Noah J. Mathis +20
Medicine · #Bone health and treatments #Management of metastatic bone disease #Medical Imaging Techniques and Applications
paper · doi:10.1200/jco.23.00753
openalex publication_date 2023/09/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
PURPOSE: External-beam radiation therapy (RT) is standard of care (SOC) for pain relief of symptomatic bone metastases. We aimed to evaluate the efficacy of radiation to asymptomatic bone metastases in preventing skeletal-related events (SRE). METHODS: In a multicenter randomized controlled trial, adult patients with widely metastatic solid tumor malignancies were stratified by histology and planned SOC (systemic therapy or observation) and randomly assigned in a 1:1 ratio to receive RT to asymptomatic high-risk bone metastases or SOC alone. The primary outcome of the trial was SRE. Secondary outcomes included hospitalizations for SRE and overall survival (OS). RESULTS: = .01). CONCLUSION: Radiation delivered prophylactically to asymptomatic, high-risk bone metastases reduced SRE and hospitalizations. We also observed an improvement in OS with prophylactic radiation, although a confirmatory phase III trial is warranted.