THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to Pathology

1999/04/01 by Jean-Pierre Kinet, Jean‐Pierre Kinet · 3 citations
Immunology and Microbiology · Medicine · #Immune Cell Function and Interaction #Monoclonal and Polyclonal Antibodies Research #T-cell and B-cell Immunology

paper · doi:10.1146/annurev.immunol.17.1.931

openalex publication_date 1999/04/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/31

Abstract

The high affinity receptor for immunoglobulin E (designated Fc epsilon RI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific IgEs with cellular immunologic effector functions. This review provides background information on Fc epsilon RI function combined with more detailed summaries of recent progress in understanding specific aspects of Fc epsilon RI biology and biochemistry. Topics covered include the coordination and function of the large multiprotein signaling complexes that are assembled when Fc epsilon RI and other Ag receptors are engaged, new information on human receptor structures and tissue distribution, and the role of the FcR beta chain in signaling and its potential contribution to atopic phenotypes.

Citations

• Enhanced expression of high-affinity IgE receptor (FcϵRI) α chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells☆☆☆★

Cited by

• Critical roles of plasma membrane dynamics and heterogeneity at the early stage of antigen-stimulated FcεRI signaling in mast cells
• FcεR1-expressing nociceptors trigger allergic airway inflammation
• Naturally occurring polyphenolic antioxidants modulate IgE‐mediated mast cell activation

Related

• On the role of antibody affinity and avidity in the IgE‐mediated allergic response
• F c RECEPTOR BIOLOGY
• The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces
• Targeting the neonatal Fc receptor ( FcRn ) to treat autoimmune diseases and maternal‐fetal immune cytopenias
• Critical roles of plasma membrane dynamics and heterogeneity at the early stage of antigen-stimulated FcεRI signaling in mast cells