Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide

2025/08/04 by Steven V John, Steven V. John, Gretchen L. Seim +16 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Neuroscience · #Immune cells in cancer #Receptor Mechanisms and Signaling #Tryptophan and brain disorders

paper · doi:10.1038/s42255-025-01337-3

openalex publication_date 2025/08/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• Mitochondrial DNA in inflammation and immunity

Cited by

• Metabolic reprogramming and intracellular ATP homeostasis in immunity

Discussions

• Classical macrophage activation reprograms nucleotide metabolism by suppressing de novo synthesis and enhancing salvage pathways (through nitric oxide...) @natmetabolism.nature.com doi.org/10.1038/s42 [bsky, 9 points, 0 comments]