Autophagosome Formation in Mammalian Cells.

2002/01/01 by Noboru Mizushima, Yoshinori Ohsumi, Tamotsu Yoshimori · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Endoplasmic Reticulum Stress and Disease #Ubiquitin and proteasome pathways

paper · pdf · doi:10.1247/csf.27.421

openalex publication_date 2002/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Macroautophagy is an intracellular degradation system for the majority of proteins and some organelles. The molecular mechanism of autophagy has been extensively studied using the yeast, Saccharomyces cerevisiae, during these past 10 years. These studies suggested that the molecular machinery of autophagosome formation is well conserved from yeast to higher eukaryotes. Identification and characterization of the mammalian counterparts of the yeast autophagy proteins has facilitated our understanding of mammalian autophagy, particularly of autophagosome formation. These findings are now being applied to studies on the physiological roles of autophagy in mammals.

Citations

• Bafilomycin A1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells.
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
• THE UBIQUITIN SYSTEM

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