2012/09/26 by Shingo Uno, Kazuhiko Kimachi, Fujio Matsuo +6
Agricultural and Biological Sciences · Medicine · #Animal Disease Management and Epidemiology #Influenza Virus Research Studies #Respiratory viral infections research
paper · pdf · doi:10.1111/j.1348-0421.2012.00511.x
openalex publication_date 2012/09/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 2007-2008 season but not in the other two seasons. The proportion of individuals with HI antibody titers ≥ 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.