2009/01/14 by Rika Kano, Satoru Konnai, Misao Onuma +1
Medicine · #Cytomegalovirus and herpesvirus research #Herpesvirus Infections and Treatments #Systemic Lupus Erythematosus Research
paper · pdf · doi:10.1111/j.1348-0421.2009.00109.x
openalex publication_date 2009/01/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Marek's disease has been controlled byvaccination with avirulent strains of MDV. However, the protection mechanism following vaccination is not fully understood. In this study immune responses of PBMC and splenocytes derived from vaccinated chickens challenged with virulent MDV were examined using real-time PCR and ELISA. Higher levels of IFN-gamma induction were observed in chickens vaccinated during the latent phase of infection with virulent MDV than in similarly challenged, unvaccinated chickens. Furthermore, the mean expression of IFNGR2 and IFN regulatory factor-3 mRNAs was significantly higher in vaccinated than in unvaccinated chickens. These results show that IFN-gamma could be one of the important factors in prevention of MD by vaccination and is effective during the latent phase of the infection.