2016/06/09 by Nguyen Van Nguyen, Sei‐ich Kato, Kyosuke Nagata +1
Immunology and Microbiology · Medicine · #SARS-CoV-2 and COVID-19 Research #Virology and Viral Diseases #interferon and immune responses
paper · pdf · doi:10.1111/1348-0421.12392
openalex publication_date 2016/06/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Measles vaccines are highly effective and safe; however, the mechanism(s) underlying their attenuation has not been well understood. In this study, type I IFNs (IFN-α and IFN-β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild-type MV. However, IFN-α was sharply induced in most macaques infected with recombinant wild-type MV bearing the hemagglutinin (H) protein of the Edmonston vaccine strain. These results indicate that the H protein of MV vaccine strains may have a role in MV attenuation.