2026/07/01 by Pinyadapat Aroonthongsawat, Xue Feng, Yuxuan Ji +8
Biochemistry, Genetics and Molecular Biology · Engineering · Materials Science · #Curcumin's Biomedical Applications #Nanoparticle-Based Drug Delivery #Nanoplatforms for cancer theranostics
paper · pdf · doi:10.1016/j.ijpharm.2026.127202
openalex publication_date 2026/07/27 · openalex created_date 2026/07/28 · openalex updated_date 2026/08/03
In this study, a multifunctional nanoplatform based on a self-assemble curcumin and indocyanine green nanodrug core, coated with polydopamine, and functionalized with anti-CD33 antibodies is evaluated for potential AML therapy. Indocyanine green drives stable co-assembly with curcumin, while the polydopamine layer improves photostability, enables pH-responsive release under acidic intracellular conditions, and provides versatile chemistry for antibody immobilization. Anti-CD33 antibody functionalization was designed to promote CD33-associated cellular uptake into AML cells. In vitro studies demonstrated that Ab@pDCur-ICG NPs achieved significantly higher uptake and cytotoxicity in CD33-positive cells than in CD33-negative controls, with uptake reduced upon antibody blocking. Under near-infrared irradiation, the nanoparticles produced synergistic chemo-photothermal effects, resulting in greater cell death in CD33-positive leukemia cells. This antibody-functionalized, multimodal nanoplatform integrates high drug loading, antibody-assisted delivery, and synergistic therapy, representing a promising strategy to improve AML outcomes and potentially extend to other hematological malignancies.