Unravelling monocyte functions: from the guardians of health to the regulators of disease

2024/01/01 by Alexander Mildner, Ki-Wook Kim, Simon Yona · 1 voice
Immunology and Microbiology · Medicine · #Adipokines, Inflammation, and Metabolic Diseases #Immune cells in cancer #Immune responses and vaccinations

paper · pdf · doi:10.1093/discim/kyae014

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.

Citations

• Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury
• Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
• Obesity is associated with macrophage accumulation in adipose tissue
• A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
• Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
• Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis?
• Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer
• TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
• A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
• Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
• Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

Discussions

• 🍬Our 2024 update🍬 on monocytes their origins and development - with @kim-lab.bsky.social and Alex Mildner - The image below uses a 'sweet shop analogy' to illustrate the plasticity of monocytes duri [bsky, 10 points, 0 comments]

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