Enteroendocrine cells regulate intestinal barrier permeability

2025/03/17 by Jennifer G. Nwako, Jennifer Nwako, Sparsh D. Patel +5
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Barrier Structure and Function Studies #Connexins and lens biology #Gut microbiota and health

paper · pdf · doi:10.1152/ajpcell.01077.2024

openalex publication_date 2025/03/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

There are no therapies that directly improve the permeability of the intestinal epithelial barrier. This work uses a human intestinal epithelial model system to demonstrate that sensory enteroendocrine cells are necessary for healthy barrier function and that two of their secreted products, peptide YY and somatostatin, are sufficient to improve barrier function at homeostasis and in the presence of inflammatory cytokines. This could provide novel treatments for strengthening the epithelial barrier in human gastrointestinal disease.

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