2020/12/09 by Kristy E. Gilman, Kirsten H. Limesand
Biochemistry, Genetics and Molecular Biology · Medicine · #Inflammatory mediators and NSAID effects #NF-κB Signaling Pathways #Sesquiterpenes and Asteraceae Studies
paper · doi:10.1152/ajpregu.00185.2020
openalex publication_date 2020/12/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E 2 (PGE 2 ) being the most complex and exhibiting the most diverse physiological outputs. PGE 2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE 2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.