2025/12/29 by Shaji Kumar, Joshua Richter, Saad Z. Usmani +7
Medicine · #Glioma Diagnosis and Treatment #Malaria Research and Control #Multiple Myeloma Research and Treatments
paper · doi:10.1002/ajh.70138
openalex publication_date 2025/12/29 · openalex created_date 2025/12/30 · openalex updated_date 2026/08/01
Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion molecules, heterogeneous genetic and epigenetic changes, and a solid tumor-like architecture within the microenvironment. Although the introduction of advanced imaging techniques and immunotherapy has led to improved detection and more promising outcomes and regimens, respectively, more prospective studies dedicated to true EMD are needed.