Vitamin B12–mediated microglial immunometabolic reprogramming: A novel mechanistic insight into diabetes-associated cognitive impairment

2026/07/01 by Xin Zhang, J Li, Jing Li +7
Medicine · Neuroscience · #Folate and B Vitamins Research #Neuroinflammation and Neurodegeneration Mechanisms #Tryptophan and brain disorders

paper · doi:10.1016/j.pnpbp.2026.111861

openalex publication_date 2026/07/01 · openalex created_date 2026/07/27 · openalex updated_date 2026/07/28

Citations

• Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
• Vitamin B12, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
• Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition
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• Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice
• Metabolic Profiling Reveals a Glycolytic Shift and an IRG1 /Itaconate/ NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia