The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man.
1984/04/01 by R C Spiller, Robert E. Spiller, I F Trotman +11 · 26 citations
Medicine · #Gastrointestinal motility and disorders #Diet and metabolism studies #Gastroesophageal reflux and treatments
paper · pdf · doi:10.1136/gut.25.4.365
Abstract
The possibility that malabsorbed fat passing through the human ileum exerts an inhibitory feedback control on jejunal motility has been investigated in 24 normal subjects by perfusing the ileum with a fat containing solution designed to produce ileal luminal fat concentrations similar to those in steatorrhoea (30-40 mg/ml). Mean transit times through a 30 cm saline perfused jejunal segment were measured by a dye dilution technique. Thirty minutes after ileal fat perfusion, mean transit times rose markedly to 18.9 +/- 2.5 minutes from a control value of 7.5 +/- 0.9 minutes (n = 5; p less than 0.05). This was associated with an increase in volume of the perfused segment which rose to 175.1 +/- 22.9 ml (control 97.6 +/- 10.3 ml, n = 5; p less than 0.05). Transit times and segmental volumes had returned towards basal values 90 minutes after completing the fat perfusion. Further studies showed that ileal fat perfusion produced a pronounced inhibition of jejunal pressure wave activity, percentage duration of activity falling from a control level of 40.3 +/- 5.0% to 14.9 +/- 2.8% in the hour after ileal perfusion (p less than 0.01). Ileal fat perfusion was associated with marked rises in plasma enteroglucagon and neurotensin, the peak values (218 +/- 37 and 68 +/- 13.1 pmol/l) being comparable with those observed postprandially in coeliac disease. These observations show the existence in man of an inhibitory intestinal control mechanism, whereby ileal fat perfusion inhibits jejunal motility and delays caudal transit of jejunal contents.
Cited by
- Gastric Motor and Sensory Functions in Obesity
- Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. [europepmc]
- Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. [europepmc]
- Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus. [europepmc]
- Effects on GLP-1, PYY, and leptin by direct stimulation of terminal ileum and cecum in humans: implications for ileal transposition. [europepmc]
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions. [europepmc]
- Association of high dietary saturated fat intake and uncontrolled diabetes with constipation: evidence from the National Health and Nutrition Examination Survey. [europepmc]
- Enteroendocrine cells: a review of their role in brain-gut communication. [europepmc]
- Gastrointestinal Nutrient Infusion Site and Eating Behavior: Evidence for A Proximal to Distal Gradient within the Small Intestine? [europepmc]
- Cumulative Length of Bowel Resection in a Population-Based Cohort of Patients With Crohn's Disease. [europepmc]
- Exploring hypotheses and rationale for causes of infantile colic. [europepmc]
- Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. [europepmc]
- Relationship of body weight with gastrointestinal motor and sensory function: studies in anorexia nervosa and obesity. [europepmc]
- Dietary fiber in irritable bowel syndrome (Review). [europepmc]
- Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome. [europepmc]
- Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review). [europepmc]
- Small Intestinal Bacterial Overgrowth Is Common in Chronic Pancreatitis and Associates With Diabetes, Chronic Pancreatitis Severity, Low Zinc Levels, and Opiate Use. [europepmc]
- Incretins in obesity and diabetes. [europepmc]
- Factors That Affect Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: A Systematic Review, Meta-Analysis, and Meta-Regression. [europepmc]
- Carbohydrates designed with different digestion rates modulate gastric emptying response in rats. [europepmc]
- The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders. [europepmc]
- The metabolic impact of small intestinal nutrient sensing. [europepmc]
- Association of gastric emptying with postprandial appetite and satiety sensations in obesity. [europepmc]
- Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry. [europepmc]
- Asian-Pacific consensus on small intestinal bacterial overgrowth in gastrointestinal disorders: An initiative of the Indian Neurogastroenterology and Motility Association. [europepmc]
- Circadian rhythms in colonic function. [europepmc]
Related