The Thrombogram: Monitoring Thrombin Generation in Platelet Rich Plasma

2000/01/01 by Peter Giesen, Manoj K. Ramjee, Manoj Ramjee +5 · 1 citation
Medicine · #Antiplatelet Therapy and Cardiovascular Diseases #Blood Coagulation and Thrombosis Mechanisms #Platelet Disorders and Treatments

paper · pdf · doi:10.1055/s-0037-1613868

openalex publication_date 2000/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28

Abstract

A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

Cited by

• Influence of vortical structures on fibrin clot formation in cerebral aneurysms: A two-dimensional computational study

Related

• Thrombin Generation Assays: What are the Current Clinical Applications?
• The Nature and Significance of Platelet Products in Human Plasma
• Thrombin: A Pivotal Player in Hemostasis and Beyond
• Phenotyping the Clotting System
• Assessing the Methodology for Calculating Platelet Contribution to Clot Strength (Platelet Component) in Thromboelastometry and Thrombelastography