Bleeding Symptoms in Carriers of Hemophilia A and B

1988/01/01 by E. P. Mauser Bunschoten, E P Mauser Bunschoten, Hans C. van Houwelingen +7
Medicine · #Hemophilia Treatment and Research #Parvovirus B19 Infection Studies #Platelet Disorders and Treatments

paper · pdf · doi:10.1055/s-0038-1647493

openalex publication_date 1988/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03

Abstract

In order to investigate the bleeding tendency in clinically identified carriers of hemophilia, a self-administered questionnaire was held among 135 carriers of hemophilia A and B, 25 females with relatives with hemophilia and a matched group consisting of 60 females without relatives with hemophilia. Carriers of hemophilia appeared to suffer more often from bleeding than their relatives or the matched unrelated control group. A relation was seen between factor VIII:C or IX:C activity and the tendency to bleed. Obligatory carriers with normal factor VIII:C levels showed no bleeding tendency and were in this respect similar to a group of 25 females with relatives with hemophilia. This study shows that it is important to assay factor VIII:C or IX:C also in those women in whom the carrier status has already been established otherwise.

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