2025/11/29 by Lauren M Ackermann, Amanda Ro, Barbara Dunn +4 · 1 voice
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Fermentation and Sensory Analysis #Fungal and yeast genetics research
paper · doi:10.17912/micropub.biology.001962
openalex publication_date 2025/11/29 · openalex created_date 2026/02/14 · openalex updated_date 2026/07/01
with traits complementary to different beers, but these strains may also harbor undesirable characteristics. One example is the mother-daughter separation defect (MDSD) which is present in London Ale III, a popular brewing strain, and causes cells to form large clusters. MDSDs can be caused by mutations to several genes, making targeted genetic approaches to reduce MDSDs challenging. We passaged three populations for over 200 generations to generate strains with reduced MDSD, demonstrating how experimental evolution can be used to select against undesirable traits in industrial yeast strains.