Global patterns and trends in colorectal cancer incidence and mortality
2016/01/27 by Melina Arnold, Mónica S. Sierra, Mónica S Sierra +4 · 34 citations
Medicine · #Colorectal Cancer Screening and Detection #Global Cancer Incidence and Screening #Colorectal Cancer Treatments and Studies
paper · pdf · doi:10.1136/gutjnl-2015-310912
Abstract
OBJECTIVE: The global burden of colorectal cancer (CRC) is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. In this study, we aim to describe the recent CRC incidence and mortality patterns and trends linking the findings to the prospects of reducing the burden through cancer prevention and care. DESIGN: (CI5) volumes I-X and the WHO mortality database. Trends were assessed via the annual percentage change using joinpoint regression and discussed in relation to human development levels. RESULTS: CRC incidence and mortality rates vary up to 10-fold worldwide, with distinct gradients across human development levels, pointing towards widening disparities and an increasing burden in countries in transition. Generally, CRC incidence and mortality rates are still rising rapidly in many low-income and middle-income countries; stabilising or decreasing trends tend to be seen in highly developed countries where rates remain among the highest in the world. CONCLUSIONS: Patterns and trends in CRC incidence and mortality correlate with present human development levels and their incremental changes might reflect the adoption of more western lifestyles. Targeted resource-dependent interventions, including primary prevention in low-income, supplemented with early detection in high-income settings, are needed to reduce the number of patients with CRC in future decades.
Cited by
- Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
- International Trends in the Incidence of Cancer Among Adolescents and Young Adults
- The Role of the Microbiome in the Etiopathogenesis of Colon Cancer
- Role of community pharmacies in a population-based colorectal cancer screening program
- A shared frailty regression model for clustered survival data
- Trends in cancer mortality in the elderly and oldest old in South America
- Colorectal cancer statistics, 2026
- Increase of early-onset colorectal cancer: a cohort effect
- Large-scale Searching for Causal Relationships of Body Mass Index Bridged Modifiable Lifestyle Factors on Colorectal Cancer Risk: A phenome-Wide Mendelian Randomization Study
- Incidence and mortality of lung cancer: global trends and association with socioeconomic status. [europepmc]
- The IARC Perspective on Colorectal Cancer Screening. [europepmc]
- Sex Differences in Cancer: Epidemiology, Genetics and Therapy. [europepmc]
- An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients. [europepmc]
- The Human Gut Microbiome - A Potential Controller of Wellness and Disease. [europepmc]
- Changes in lipids composition and metabolism in colorectal cancer: a review. [europepmc]
- Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. [europepmc]
- Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. [europepmc]
- Changes in colorectal cancer incidence in seven high-income countries: a population-based study. [europepmc]
- Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. [europepmc]
- The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. [europepmc]
- Concise update on colorectal cancer epidemiology. [europepmc]
- Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer. [europepmc]
- Colorectal Cancer Immunotherapy: Options and Strategies. [europepmc]
- Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers. [europepmc]
- Rising incidence of early-onset colorectal cancer - a call to action. [europepmc]
- The Intestinal Microbiota and Colorectal Cancer. [europepmc]
- A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis. [europepmc]
- The Role of p53 Signaling in Colorectal Cancer. [europepmc]
- Global colorectal cancer burden in 2020 and projections to 2040. [europepmc]
- A global assessment of recent trends in gastrointestinal cancer and lifestyle-associated risk factors. [europepmc]
- Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer. [europepmc]
- Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance. [europepmc]
- Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. [europepmc]
- Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy. [europepmc]
Related