Using demographics of patients to inform treatment of shigellosis in England

2024/11/12 by Lewis C. E. Mason, Daniel Richardson, Hannah Charles +6 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Escherichia coli research studies #Hepatitis Viruses Studies and Epidemiology #Viral gastroenteritis research and epidemiology

paper · doi:10.1016/j.lanmic.2024.101026

openalex publication_date 2024/11/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

Shigellosis, caused by bacteria of the genus Shigella, is a diarrhoeal disease transmitted by the faecal–oral route.1 Rapid increases in the prevalence of extensively drug-resistant (XDR) Shigella isolates—also known as triple-resistant due to resistance to fluoroquinolones, third-generation cephalosporins, and azithromycin—during the final quarter of 2021 and the first quarter of 2022 in Europe, Northern America, and Australia have highlighted the urgent need to develop new antimicrobials and vaccines targeting high-priority Shigella spp.

Citations

• The re-emergence of sexually transmissible multidrug resistant Shigella flexneri 3a, England, United Kingdom

Cited by

• The natural history of the emergence of sexually transmissible shigellosis

Discussions

• Proportion of Shigella from UK🇬🇧 resistant to 3 key antibiotics (Azithromycin, Ciprofloxacin, Ceftriaxone) MSM and travel to Asia are 🔑 risk factors Alternative empirical choices to consider: ➡ [bsky, 11 points, 2 comments]

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