2025/01/01 by Abdelhak Lachguar, Till Neumann, Andrey V. Pichugov +4 · 1 voice · 1 citation
Pharmacology, Toxicology and Pharmaceutics · #Chemical Reactions and Isotopes
paper · pdf · doi:10.1039/d4dt03171g
M'Cp*], combining early transition metals (M = Hf, Ta) with late metals (M' = Ir, Os), were synthesized and evaluated for their catalytic activity in HIE of (hetero)arenes. Hafnium-iridium and hafnium-osmium complexes showed a clear improvement in catalytic efficiency and reaction rate over monometallic analogues, suggestive of metal-metal synergy. Conversely, the tantalum-based heterobimetallic complexes showed lower catalytic performance, revealing that not all metal combinations are equally effective. These results underline the importance of careful metal selection to optimize transition metal cooperativity, and open up new possibilities for the design of more efficient H/D exchange catalysts.