Inhibitor-resistant TEM -lactamases: phenotypic, genetic and biochemical characteristics

1999/04/01 by E. B. Chaibi, El Bachir Chaibi, D. Sirot +3 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Antibiotic Resistance in Bacteria #Bacterial biofilms and quorum sensing #Plant Pathogenic Bacteria Studies

paper · doi:10.1093/jac/43.4.447

openalex publication_date 1999/04/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/30

Abstract

Beta-lactamases represent the main mechanism of bacterial resistance to beta-lactam antibiotics. The recent emergence of bacterial strains producing inhibitor-resistant TEM (IRT) enzymes could be related to the frequent use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam in hospitals and in general practice. The IRT beta-lactamases differ from the parental enzymes TEM-1 or TEM-2 by one, two or three amino acid substitutions at different locations. This paper reviews the phenotypic, genetic and biochemical characteristics of IRT beta-lactamases in an attempt to shed light on the pressures that have contributed to their emergence.

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• Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

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