1977/01/01 by B. G. Spratt · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Analytical Chemistry and Chromatography #Antibiotic Resistance in Bacteria #Antibiotics Pharmacokinetics and Efficacy
paper · doi:10.1093/jac/3.suppl_b.13
openalex publication_date 1977/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Morphological, biochemical and genetic studies have shown that penicillin-binding protein 2 of Escherichia coli is the target at which mecillinam interacts to result in the production of osmotically-stable round cells. The mechanism of action appears to be identical in a wide variety of Gram-negative rod-shaped bacteria including Salmonella typhimurium, Kiebsiella aerogenea, Serratis marcescens and Pseudomonas fluorescens . In Bacillus subtilis mecillinam probably acts as a typical, but relatively ineffective β-lactam.