Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae

2001/05/01 by Leticia Zarantonelli, L. Zarantonelli, Graciela Borthagaray +7 · 3 citations
Immunology and Microbiology · Medicine · #Bacterial Infections and Vaccines #Pneumonia and Respiratory Infections #Reproductive tract infections research

paper · doi:10.1093/jac/47.5.651

openalex publication_date 2001/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded efflux pump system, but remained susceptible to Triton X-100. We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.

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