SMART 5: domains in the context of genomes and networks

2005/12/28 by I. Letunic, Ivica Letunić · 3 citations
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genomics and Phylogenetic Studies #Machine Learning in Bioinformatics

paper · pdf · doi:10.1093/nar/gkj079

openalex publication_date 2005/12/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of domain interactions.

Citations

• Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

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