Diazepam, a positive allosteric modulator of the GABAA receptor, induces strain-specific responses in object recognition, ultrasonic vocalizations and monoaminergic profiles in the Wistar Kyoto rat model of endogenous depression

2026/07/25 by Akshata T. Inavally, Monika Sadananda
Psychology · Neuroscience · #Neuroendocrine regulation and behavior #Neuroscience and Neuropharmacology Research #Neurotransmitter Receptor Influence on Behavior

paper · doi:10.1016/j.neulet.2026.138690

Citations

• Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats
• The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma
• A comparison between Dark Agouti and Sprague-Dawley rats in their behaviour on the elevated plus-maze, open-field apparatus and activity meters, and their response to diazepam
• Behavioral analysis of diazepam-induced memory deficits: evidence for sedation-like effects
• Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression
• What are We Measuring When We Test Strain Differences in Anxiety in Mice?
• Central monoamine levels differ between rat strains used in studies of depressive behavior
• Depletion of brain norepinephrine: differential influence on anxiolyic treatment effects
• Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression