Pentahaem cytochrome c nitrite reductase: reaction with hydroxylamine, a potential reaction intermediate and substrate

2002/08/01 by Marc Rudolf, M. Rudolf, O. Einsle +5 · 2 citations
Biochemistry, Genetics and Molecular Biology · Energy · Medicine · #Amino Acid Enzymes and Metabolism #Metalloenzymes and iron-sulfur proteins #Nitric Oxide and Endothelin Effects

paper · doi:10.1042/bst0300649

openalex publication_date 2002/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

The pentahaem enzyme cytochrome c nitrite reductase catalyses the reduction of nitrite to ammonia, a key reaction in the biological nitrogen cycle. The enzyme can also transform nitrogen monoxide and hydroxylamine, two potential bound reaction intermediates, into ammonia. Structural and mechanistic aspects of the multihaem enzyme are discussed in comparison with hydroxylamine oxidoreductase, a trimeric protein with eight haem molecules per subunit.

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• Substrate binding and activation in the active site of cytochrome c nitrite reductase: a density functional study
• Recent mechanistic developments for cytochrome c nitrite reductase, the key enzyme in the dissimilatory nitrate reduction to ammonium pathway

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