2021/02/22 by Yoshihiro Nakamura, Hiroki Kobayashi, Sho Tanaka +3
paper · doi:10.1111/cen.14434
Abstract Objective Although renal impairments are observed in patients with primary aldosteronism (PA), the association between plasma aldosterone concentration (PAC) and specific structural kidney damage remains unknown. Thus, we analysed the association between PAC, and markers of glomerular and tubular damage. Design This was a retrospective cross‐sectional study of 96 PA patients, in which we analysed the association between PAC and markers of kidney damage, including urinary albumin‐creatinine ratio (ACR) for glomerular damage, and urinary liver fatty acid‐binding protein (L‐FABP), N‐acetyl‐β‐D‐glucosaminidase (NAG) and β2‐microglobulin (β2‐MG) for tubular damage. In addition, we evaluated the association between PAC and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) as a marker for body fluid volume. Results Urinary ACR, L‐FABP, NAG, β2‐MG and NT‐proBNP significantly correlated with PAC. PAC ( 2 ), with its optimal cut‐offs for predicting each, 558 and 594 pmol/L, respectively. Conclusions Increased PAC, especially over 550 pmol/L, is associated with excessive damage to the tubule and glomerulus.