2022/03/04 by Matthew Hunt, Richard Odame Phillips, Richard Phillips +9
Medicine · #HIV-related health complications and treatments #HIV/AIDS drug development and treatment #Pharmacological Effects and Toxicity Studies
paper · doi:10.1097/qad.0000000000003209
openalex publication_date 2022/03/04 · openalex created_date 2022/06/13 · openalex updated_date 2026/08/01
We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from thymidine analogue to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not thymidine analogue-treated PWH. These data support the continued use of TDF in resource-limited settings.