Evolutionary fingerprints of epithelial-to-mesenchymal transition

2025/03/05 by Luigi Perelli, Li Zhang, Sarah Mangiameli +39 · 1 voice · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer Genomics and Diagnostics #Pancreatic and Hepatic Oncology Research #Single-cell and spatial transcriptomics

paper · doi:10.1038/s41586-025-08671-2

openalex publication_date 2025/03/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Citations

• The basics of epithelial-mesenchymal transition
• Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer
• Single-cell transcriptional diversity is a hallmark of developmental potential
• Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2
• Integrated analysis of multimodal single-cell data
• Hallmarks of Cancer: New Dimensions

Cited by

• Epithelial-to-mesenchymal transition as a central driver of tumor cell plasticity
• Evidence for improved DNA repair in the long-lived bowhead whale
• EMT and cancer: what clinicians should know

Discussions

• "EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chick [bsky, 7 points, 1 comments]