2025/03/13 by Moritz Gerster, Gunnar Waterstraat, Thomas S. Binns +30 · 1 voice · 1 citation
Medicine · Neuroscience · #Genetic Neurodegenerative Diseases #Neurological disorders and treatments #Parkinson's Disease Mechanisms and Treatments
paper · pdf · doi:10.1101/2025.03.11.642600
openalex publication_date 2025/03/13 · openalex created_date 2025/03/14 · openalex updated_date 2026/07/22
Abstract Parkinson’s disease is linked to increased beta oscillations in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies have varied. Our standardized analysis of multicenter datasets shows that small sample sizes contributed to these discrepancies—a challenge we address by pooling datasets into one large cohort (n=119). Moving beyond beta power, we disentangled spectral components reflecting distinct neural processes. Combining aperiodic offset, low beta, and low gamma oscillations explained significantly more variance in symptom severity than beta alone. Moreover, interhemispheric within-patient analyses showed that, unlike beta oscillations, aperiodic broadband power–likely reflecting spiking activity–was increased in the more affected hemisphere. These findings identify aperiodic broadband power as a potential biomarker for adaptive deep brain stimulation and provide novel insights into the relationship between subthalamic hyperactivity and motor symptoms in human Parkinson’s disease.